Prep the Chicken: Bone out the chicken thighs, trim off any extra skin and cartilage, and cut each thigh in half.
Make the Brine: In a bowl, mix buttermilk, Louisiana hot sauce, garlic powder, mustard powder, and salt. Whisk until well combined and the salt is dissolved.
Brine the Chicken: Place the chicken in the brine, ensuring it's fully covered. Marinate for at least 12 hours in the fridge.
Prepare the Dredge: Season all-purpose flour with salt and fresh cracked black pepper.
Dredge the Chicken: Remove chicken from the brine, allowing excess to drip off, and coat evenly in the seasoned flour. Allow the first coat to absorb for 25-30 minutes, then dredge again for a thicker crust.
Fry the Chicken: Heat oil in a cast iron pan. Fry the chicken, flipping once, until golden brown and crispy, about 4 minutes per side.
Drain and Serve: Drain the fried chicken on a rack to keep it crispy. Serve hot.